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The ‘blue pill’ – or the ‘little
blue pill’ – is a common nickname
In volunteers with severe renal impairment (creatinine clearance <30 mL/min), sildenafil clearance was reduced, resulting in mean increases in AUC and Cmax of 100% and 88% respectively compared to age-matched volunteers with no renal impairment. In addition, N-desmethyl metabolite AUC and Cmax values were significantly increased by 200% and 79% respectively. In volunteers with mild to moderate hepatic cirrhosis (Child-Pugh A and B) sildenafil clearance was reduced, resulting in increases in AUC (84%) and Cmax (47%) compared to age-matched volunteers with no hepatic impairment. The pharmacokinetics of sildenafil in patients with severely impaired hepatic function have not been studied. Non-clinical data revealed no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction and development.
This medicinal product does not require any special storage conditions. PVC/Aluminium foil blisters in cartons of 1, 2, 4, 8, 12 or 24 tablets. PVC/Aluminium foil blisters in cartons of 1, 2, 4, 8, 12, 16 or 24 tablets. Not all pack sizes may be marketed. The pill with imprint M SL 100 (Blue, Round, 11 mm) has been identified as Sildenafil Citrate 100 mg and is used for Erectile Dysfunction, and Pulmonary Arterial Hypertension. used for Viagra, possibly the most well-known
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Original | 100mg | 64 + 4 Pills | 264.15€ 251.57€ | |
| Kamagra 100 mg | 100 mg | 360 + 6 Pills | 839.95€ 799.95€ | |
| Kamagra Oral Jelly | 100 mg | 110 + 9 Sachets | 334.87€ 318.92€ | |
| Priligy Generic Dapoxetine | 60mg | 20 + 4 Pills | 77.31€ 73.63€ | |
| Kamagra Oral Jelly | 100mg | 110 + 9 Sachets | 334.87€ 318.92€ | |
| Viagra Generic | 50mg | 360 + 10 Pills | 225.33€ 214.60€ | |
| Levitra Generic | 20mg | 120 + 10 Pills | 224.15€ 213.48€ | |
| Kamagra 100 mg | 100 mg | 32 Pills | 121.24€ 115.47€ | |
| Levitra Original | 20mg | 14 + 2 Pills | 102.27€ 97.40€ | |
| Viagra Oral Jelly | 100mg | 110 + 9 Sachets | 284.63€ 271.08€ | |
| Viagra Original | 100mg | 12 Pills | 72.54€ 69.09€ | |
| Super Kamagra | 160 mg | 8 Pills | 69.23€ 65.93€ | |
| Kamagra Gold | 50 mg | 12 Pills | 47.30€ 45.05€ | |
| Cialis Generic | 40mg | 20 Pills | 59.47€ 56.64€ | |
| Viagra Soft Tabs | 100mg | 60 + 6 Pills | 152.94€ 145.66€ | |
| Viagra Oral Jelly | 100mg | 63 + 7 Sachets | 190.54€ 181.47€ | |
| Viagra Generic | 50mg | 30 + 4 Pills | 54.26€ 51.68€ |
erectile dysfunction (ED) medication on the market.
Created back in 1998, Viagra was
In a small size placebo-controlled study of patients with documented early age-related macular degeneration (n=9), sildenafil (single dose, 100 mg) demonstrated no significant changes in the visual tests conducted (visual acuity, Amsler grid, colour discrimination simulated traffic light, Humphrey perimeter and photostress). There was no effect on sperm motility or morphology after single 100 mg oral doses of sildenafil in healthy volunteers (see section 4.6). In clinical trials sildenafil was administered to more than 8000 patients aged 19-87. The following patient groups were represented: elderly (19.9%), patients with hypertension (30.9%), diabetes mellitus (20.3%), ischaemic heart disease (5.8%), hyperlipidaemia (19.8%), spinal cord injury (0.6%), depression (5.2%), transurethral resection of the prostate (3.7%), radical prostatectomy (3.3%). The following groups were not well represented or excluded from clinical trials: patients with pelvic surgery, patients post-radiotherapy, patients with severe renal or hepatic impairment and patients with certain cardiovascular conditions (see section 4.3).
In fixed dose studies, the proportions of patients reporting that treatment improved their erections were 62% (25 mg), 74% (50 mg) and 82% (100 mg) compared to 25% on placebo. In controlled clinical trials, the discontinuation rate due to sildenafil was low and similar to placebo. Across all trials, the proportion of patients reporting improvement on sildenafil were as follows: psychogenic erectile dysfunction (84%), mixed erectile dysfunction (77%), organic erectile dysfunction (68%), elderly (67%), diabetes mellitus (59%), ischaemic heart disease (69%), hypertension (68%), TURP (61%), radical prostatectomy (43%), spinal cord injury (83%), depression (75%). The safety and efficacy of sildenafil was maintained in long-term studies. The European Medicines Agency has waived the obligation to submit the results of studies with sildenafil in all subsets of the paediatric population for the treatment of erectile dysfunction. the first oral treatment available for ED.
| Country | Major Manufacturers | Quality Certification | Export Volume (annually) |
|---|---|---|---|
| China | Shanghai Pharma | GMP Certified | 50 million pills |
| India | Sun Pharma | ISO Certified | 30 million pills |
| Germany | Bayer AG | EU GMP Certified | 10 million pills |
| USA | Pfizer | FDA Approved | 5 million pills |
The colour and shape of
Count on Mountainside Medical for safe, effective solutions that prioritize your well-being and help you reclaim control over your sexual health. Original price $ 19.95Current price $ 13.25Sildenafil Tablets 100 mg by Torrent 30 Count (Rx)2 reviewsSildenafil Tablets 100 mg are primarily used to treat erectile dysfunction (ED) in men by enhancing blood flow to the penis, thereby facilitating t...View full details🔒 Medical License Required Sildenafil Tablets 100 mg are primarily used to treat erectile dysfunction (ED) in men by enhancing blood flow to the penis, thereby facilitating t.. Original price $ 21.50Current price $ 16.25Sildenafil Tablets 25 mg by Torrent 30 Count (RX)No reviewsSildenafil Citrate Tablets 25 mg by Torrent Pharmaceuticals offer a reliable solution for the treatment of erectile dysfunction (ED). This product ...View full details🔒 Medical License Required Sildenafil Citrate Tablets 25 mg by Torrent Pharmaceuticals offer a reliable solution for the treatment of erectile dysfunction (ED). Original price $ 31.75Current price $ 14.85Sildenafil Tablets 50 mg by Amneal 30 Count (Rx)No reviewsSildenafil Citrate Tablets 50 mg are primarily used to treat erectile dysfunction (ED) by enhancing blood flow to the penis, aiding in achieving an...View full details🔒 Medical License Required Sildenafil Citrate Tablets 50 mg are primarily used to treat erectile dysfunction (ED) by enhancing blood flow to the penis, aiding in achieving an.. the pill have since become iconic.
Explore effective erectile dysfunction medications for improved sexual health and performance. Regain confidence and enhance intimate experiences safely. At Mountainside Medical, we provide a comprehensive selection of erectile dysfunction medications tailored to restore sexual health and improve performance. Our range includes trusted pharmaceutical options designed to enhance blood flow, ensuring stronger and longer-lasting erections for a more satisfying intimate experience. Whether you're dealing with mild or severe symptoms, our ED treatments aim to boost confidence and reinvigorate your relationship. The little blue diamond pills, stamped with the
| Condition | Details | Shelf Life | Precautions |
|---|---|---|---|
| Temperature | Store in a cool, dry place | 2-3 years | Avoid sunlight, maintain below 25°C |
| Humidity | Keep away from moisture | Use airtight container | |
| Packaging | Original blister or bottle | Keep out of reach of children |
Pfizer logo, are easily
The corresponding change in supine diastolic blood pressure was 5.5 mmHg. These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle. Single oral doses of sildenafil up to 100 mg in healthy volunteers produced no clinically relevant effects on ECG. In a study of the hemodynamic effects of a single oral 100 mg dose of sildenafil in 14 patients with severe coronary artery disease (CAD) (>70% stenosis of at least one coronary artery), the mean resting systolic and diastolic blood pressures decreased by 7% and 6% respectively compared to baseline. Mean pulmonary systolic blood pressure decreased by 9%.
Sildenafil showed no effect on cardiac output, and did not impair blood flow through the stenosed coronary arteries. A double-blind, placebo-controlled exercise stress trial evaluated 144 patients with erectile dysfunction and chronic stable angina who regularly received anti-anginal medicinal products (except nitrates). The results demonstrated no clinically relevant differences between sildenafil and placebo in time to limiting angina. Mild and transient differences in colour discrimination (blue/green) were detected in some subjects using the Farnsworth-Munsell 100 hue test at 1 hour following a 100 mg dose, with no effects evident after 2 hours post-dose. Sildenafil has no effect on visual acuity or contrast sensitivity. recognisable around the world.
This metabolite has a phosphodiesterase selectivity profile similar to sildenafil and an in vitro potency for PDE5 approximately 50% that of the parent drug. Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil. The N-desmethyl metabolite is further metabolised, with a terminal half-life of approximately 4 h. The total body clearance of sildenafil is 41 L/h with a resultant terminal phase half-life of 3-5 h. After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the faeces (approximately 80% of administered oral dose) and to a lesser extent in the urine (approximately 13% of administered oral dose).
Healthy, elderly volunteers (65 years or over) had a reduced clearance of sildenafil, resulting in approximately 90% higher plasma concentrations of sildenafil and the active N-desmethyl metabolite compared to those seen in healthy younger volunteers (18-45 years). Due to age-differences in plasma protein binding, the corresponding increase in free sildenafil plasma concentration was approximately 40%. In volunteers with mild to moderate renal impairment (creatinine clearance = 30-80 mL/min), the pharmacokinetics of sildenafil were not altered after receiving a 50 mg single oral dose. The mean AUC and Cmax of the N-desmethyl metabolite increased up to 126% and up to 73% respectively, compared to age-matched volunteers with no renal impairment. However, due to high inter-subject variability, these differences were not statistically significant.