Let's Talk About Sex

Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider. This drug comes with an extra patient fact sheet called a Medication Guide. Read it again each time this drug is refilled.

Overdose/Missed Dose

Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving. (data from updated on 2024-05-22) This information from UpToDate® Lexidrug™ explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. Low blood pressure and passing out have happened with this drug. The risk of very low blood pressure and passing out is raised if you drink alcohol close to when you take this drug. The risk is also raised if you take certain other drugs or have liver problems.

Incidence not known

Wait at least 2 hours after drinking 1 or 2 standard alcoholic drinks before you take this drug. After taking this drug at bedtime, do not drink alcohol until the next day. If you drank 3 or more standard alcoholic drinks in the evening, skip your bedtime dose. Do not take this drug if you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with this drug, like certain drugs that are used for hepatitis C, HIV, or infections. There are many drugs that must not be taken with this drug. If you have any questions about this drug, please talk with the doctor, pharmacist, or other health care provider. If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This generalized information is a limited summary of diagnosis, treatment, and/or medication information.

The Big Pink Fight for the Little Pink Pill

Skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Store at room temperature in a dry place. Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.

Lactation Precautions

Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area. If your symptoms or health problems do not get better or if they become worse, call your doctor. Do not share your drugs with others and do not take anyone else’s drugs. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider’s examination and assessment of a patient’s specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient.

Brand names

You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists. Avoid driving and doing other tasks or actions that call for you to be alert for at least 6 hours after taking this drug.

Label Warnings

Avoid these tasks or actions until you feel fully awake. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs. Talk with your doctor before you use marijuana, other forms of cannabis, or prescription or OTC drugs sex medicine that may slow your actions. Taking this drug at any other time of day may raise the chance of low blood pressure, passing out, accidental injury, and feeling sleepy. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof.

The use of this information is governed by the Terms of Use, available at The exact mechanism of action of flibanserin is unknown. Here is basic information about this medication. Treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is NOT due to: A co-existing medical or psychiatric condition The effects of a medication or other drug substance Recommended: 100 mg orally taken once daily at bedtime Discontinue treatment after 8 weeks if no improvement Moderate or strong cytochrome P450 3A4 (CYP3A4) inhibitors Please refer to the full Prescribing Information (see link below) before prescribing this medication.

• In 2019, the FDA required updates to the prescribing information regarding liver injury.
• Cases of hepatitis and liver enzyme elevations were reported post-marketing.
• Patients should be monitored for symptoms of liver injury (jaundice, dark urine).
• Discontinue flibanserin if liver injury is suspected.
• The REMS was modified to strengthen the warning about hepatotoxicity.
• Patients with signs of liver disease should not start flibanserin.
• Baseline liver enzyme testing is now considered a standard part of patient assessment.
• Follow-up testing may be recommended based on clinical judgment.
• The overall incidence of serious liver injury appears to be low.

Disclaimer: The content on this website is provided as general education for medical professionals. It is not intended or recommended for patients or other laypersons or as a substitute for medical advice, diagnosis, or treatment.

• Flibanserin's journey from failed antidepressant to HSDD treatment is unique.
• Its development cost hundreds of millions of dollars over two decades.
• The FDA initially rejected it in 2010 and 2013 due to safety/efficacy concerns.
• Final 2015 approval came with the stringent REMS and boxed warning.
• The approval process involved patient testimony and advocacy efforts.
• It is classified as a multifunctional serotonin agonist and antagonist (MSAA).
• Does not bind significantly to dopamine, norepinephrine, or histamine receptors.
• Binding affinity is highest for serotonin 5-HT1A and 5-HT2A receptors.
• Its metabolite, 6-hydroxy-flibanserin, is inactive.

Patients must always consult a qualified health care professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most recently updated information. Overview: Addyi is used in certain women to treat low sex drive (hypoactive sexual desire disorder or HSDD). It seems to work by balancing chemicals in the brain, including dopamine, norepinephrine, and serotonin.

What special dietary instructions should I follow?

Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. However, many people have no side effects or only have minor side effects.

Interactions with Food/Tobacco/Alcohol

Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. You may report side effects to your national health agency. You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at Use this drug as ordered by your doctor. Common side effects include nausea, sleepiness, and dizziness. Serious side effects are rare, but can include low blood pressure and fainting.

Real Experiences. Real Reviews.

The FDA announced the recall of a dietary supplement because it contained three undeclared drugs. The recalled dietary supplement, which was sold under the name WAP Sensual Enhancement, came in a bright red package that had its name printed in large, white letters. Best Supplements Best Prices planned to contact people who purchased the product by email and is arranging to provide full refunds on the recalled items, according to the FDA. The agency stated those who still have some of the pills should not take them. People with questions about the recall can contact Best Supplements Best Prices by emailing them at eroticenhancers@gmail.com or by calling 818-856-2141.

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The Source: Information for this article was taken from the Food and Drug Administration. Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment) Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please make sure the liquid is clear before adding the next solvent.2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. It is important to tell your healthcare provider about all of the medicines you take before and while taking Addyi.

• Flibanserin was one of the first drugs approved specifically for female hypoactive sexual desire.
• The drug's mechanism is different from that of PDE5 inhibitors used in men.
• It can induce side effects like low blood pressure and syncope, requiring caution.
• Patients should be monitored regularly for adverse effects during therapy.
• Flibanserin's approval marked significant progress in women's sexual health.
• It should be used with caution in women on other serotonergic medications.
• The medication's safety profile is still under ongoing research.
• It is not indicated for women with a history of alcohol abuse.
• The benefits of flibanserin are generally seen as modest but meaningful for some women.

Addyi (flibanserin) is commonly used to treat low sex drive (hypoactive sexual desire disorder or HSDD) in women less than 65 years of age who have not had problems with low sexual desire in the past and have low sexual desire no matter the type of sexual activity or partner. It is not for people whose low sex drive is caused by medical or mental health problems, relationship problems, or medicines or drug use. Addyi may also be used for other conditions as determined by your healthcare provider.

IMPORTANT WARNING:

Talk with your doctor and pharmacist to make sure that it is safe for you to use this drug with all of your other drugs. Do not take this drug if you have liver problems. It is used in some females to raise interest in sex. If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

Are you currently using Addyi (flibanserin)?

Do not breast-feed while you take this drug. This drug is not approved for use in people 65 or older. This drug is not approved for use in children. This drug may interact with other drugs or health problems. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. Addyi seems to work by balancing brain chemicals that affect sex drive, such as dopamine, norepinephrine, and serotonin. Addyi should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it.

• Flibanserin's side effects need to be balanced against its benefits.
• It is not recommended for use in women who are pregnant or planning pregnancy.
• The medication's pharmacodynamics involve complex neurotransmitter interactions.
• Some women may experience relapse of symptoms after discontinuation.
• The drug must be prescribed with appropriate patient counseling regarding risks.
• Its approval sparked discussions about gender disparities in drug development.
• Flibanserin’s impact on sexual desire has led to increased research interest.
• Proper patient selection is critical for optimal outcomes.
• It represents one of the few pharmacological options for HSDD.